IgA Antibodies of Cicatricial Pemphigoid Sera Specifically React with C-Terminus of BP180
نویسندگان
چکیده
منابع مشابه
BP180 as the common autoantigen in blistering diseases with different clinical phenotypes.
Bullous pemphigoid antigen 180 (BP180, type XVII collagen) is a transmembrane hemidesmosomal glycoprotein of basal keratinocytes that spans the lamina lucida of the dermal-epidermal junction. Five autoimmune subepidermal blistering diseases are associated with an immune response to BP180, including bullous pemphigoid (BP), pemphigoid gestations (PG), cicatricial pemphigoid (CP), lichen planus p...
متن کاملBP230- and BP180-specific auto-antibodies in bullous pemphigoid.
Bullous pemphigoid is a subepidermal blistering disease associated with auto-antibodies (auto-ab) to BP180 and BP230. We developed ELISAs utilizing baculovirus-encoded recombinant proteins of BP230 and BP180 and studied their diagnostic and prognostic values by assessing the profile of the auto-ab response in 127 patients with BP. 39 patients had focal involvement, whereas 88 had generalized di...
متن کاملSubconjunctival mitomycin C for the treatment of ocular cicatricial pemphigoid.
PURPOSE The authors performed a prospective evaluation of the efficacy of treating ocular cicatricial pemphigoid (OCP) with subconjunctival mitomycin C. DESIGN Unmasked, prospective, internally controlled case series. METHODS Patients were eligible for treatment with subconjunctival mitomycin C under three criteria: (1) significant complications of systemic immunosuppressant therapy; (2) ma...
متن کاملOcular Cicatricial Pemphigoid
CC (6/20/96): Red, itchy eyes, whitish discharge x 6 weeks HPI: A 74 year old retired policeman noticed red, itchy eyes associated with whitish discharge that worsened over the past six weeks. Two weeks later, the patient consulted his ophthalmologist, who treated him antibiotic eye drops without a favorable response. The patient did not respond to the antibiotic and states he was biopsied. He ...
متن کاملIgA antibodies of linear IgA bullous dermatosis recognize the 15th collagenous domain of BP180.
Arias AI, Giles B, Eiermann TH, Sterry W, Pandey JP: TNF alpha gene polymorphism in psoriasis. Clin Exp Immunogenet 14:118±122, 1997 HoÈhler T, Kruger A, Schneider PM, et al: A TNF-alpha promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis. J Invest Dermatol 109:562±565, 1997 Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T: Allele and haplotype frequen...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1999
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.1999.00501.x